Biochemoprevention for Dysplastic Lesions of the Upper Aerodigestive Tract
نویسندگان
چکیده
منابع مشابه
Biochemoprevention for dysplastic lesions of the upper aerodigestive tract.
OBJECTIVES To evaluate the efficacy and secondarily the toxic effects of biochemopreventive therapy (high-dose isotretinoin [13-cis-retinoic acid], alpha-tocopherol, and interferon alfa) in the reversal of advanced premalignant lesions of the upper aerodigestive tract and to correlate the therapeutic events with modulation of biomarkers. DESIGN Prospective, nonrandomized chemoprevention trial...
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BACKGROUND High risk head and neck mucosal premalignancy has a malignant conversion rate of up to 40%, despite adequate surgical therapy. Epidermal Growth Factor Receptor (EGFR) blocking agents, including cetuximab, have shown activity in head and neck squamous cell carcinoma (HNSCC) and have potential for therapy in high risk premalignancy. METHODS We conducted a randomized, prospective, pha...
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OBJECTIVE To identify tissue biomarkers that might be used to assess an individual's cancer risk and response to chemoprevention, we studied in dysplastic lesions of the larynx and the p.o. cavity, a series of biomarkers extensively used in previous chemoprevention trials, including chromosome polysomy (CP), proliferative status, p53 expression and gene mutations, and loss of heterozygosity at ...
متن کاملCyclin D1 genotype, response to biochemoprevention, and progression rate to upper aerodigestive tract cancer.
BACKGROUND Altered cyclin D1 expression in advanced preinvasive lesions of the upper aerodigestive tract (UADT) is associated with an increased risk of developing cancer and histologic progression during and after combination biochemopreventive therapy (13-cis-retinoic acid, alpha-interferon, and alpha-tocopherol). Both alleles of the adenine (A)/guanine (G) cyclin D1 polymorphism located at nu...
متن کاملNasopharynx- The Secret Vault for Lost Foreign Bodies of the Upper Aerodigestive Tract
Introduction: Foreign bodies in the upper aerodigestive tract often get lost following inappropriate attempts at removal. Children may present late with localized infection, posing a challenge to the otolaryngologists in a referral set-up in diagnosing and retrieving such foreign bodies. Case Report: A two-year-old boy presented with refractory purulent rhinorrhea and intermittent low-grade f...
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ژورنال
عنوان ژورنال: Archives of Otolaryngology–Head & Neck Surgery
سال: 1999
ISSN: 0886-4470
DOI: 10.1001/archotol.125.10.1083